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. 2018 Feb 13;8:2947. doi: 10.1038/s41598-018-21203-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of IOP and ICP modification on anterior retinal surface deformation (200 μm from the center of the optic nerve, relative to peripheral Bruch’s membrane plane) in 3 and 18 month old rats. Group average relative anterior surface deformation (axial change from baseline at 10 mmHg) plotted as a function of distance from the center of the optic nerve and ONPD for 3 (A) and 18 month old (B) rats. (C–E). Group average (±SEM) relative surface deformation (change from baseline at 10 mmHg) for young and older eyes as a function of IOP at ICP −5 mmHg (C, 3 month n = 5, 18 month n = 8), ICP 5 mmHg (D, 3 month n = 5, 18 month n = 6) and ICP 25 mmHg (E, 3 month n = 5, 18 month n = 8). (F) All data from panels B-D combined and plotted as a function of ONPD (mmHg).