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. 2018 Feb 13;8:2947. doi: 10.1038/s41598-018-21203-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Comparisons between structure, function and blood flow across a range of optic nerve pressure differences (IOP - ICP, mmHg) in 3 and 18 month old rats. Group averaged ganglion cell function (filled circles) is overlaid on blood flow (unfilled squares) for 3 (A) and 18 month old groups (B). Grey area indicates the 95% confidence limits derived from all young and older eyes at baseline. Group averaged residuals (ERG – blood flow %, unfilled circles) are compared with % change in RNFL thickness (grey triangles) for 3 (C) and 18 month old groups (D).