Table 2.
Pathways Enriched by Genes Associated with Schizophrenia.
| Pathways | P-value | PBH-value | Genes included |
|---|---|---|---|
| Neuroactive ligand-receptor interaction | 3.29 × 10−20 | 3.09 × 10−18 | ADRA1A, CCKAR, CHRM5, CHRNA7, CHRNB2, CNR1, DRD1, DRD2, DRD3, DRD4, DRD5, GABBR1, GABRA1, GABRA6, GABRB2, GABRG2, GABRP, GRIA1, GRIA3, GRIA4, GRID1, GRIK2, GRIK3, GRIK4, GRIN1, GRIN2A, GRIN2B, GRIN2D, GRM3, GRM4, GRM5, GRM7, GRM8, HRH1, HRH2, HTR1A, HTR2A, HTR2C, HTR4, HTR5A, HTR6, HTR7, MCHR1, TAAR6 |
| Dopaminergic synapse | 1.01 × 10−15 | 4.73 × 10−14 | AKT1, ATF6B, CLOCK, COMT, DRD1, DRD2, DRD3, DRD4, DRD5, GNAL, GNAO1, GNAS, GNB3, GRIA1, GRIA3, GRIA4, GRIN2A, GRIN2B, GSK3B, MAOA, PPP1R1B, PPP2R2B, PPP3CC, SLC18A1, SLC18A2, SLC6A3, TH |
| Cocaine addiction | 3.06 × 10−14 | 9.59 × 10−13 | ATF6B, BDNF, DRD1, DRD2, GNAS, GRIN1, GRIN2A, GRIN2B, GRIN2D, GRM3, MAOA, PDYN, PPP1R1B, SLC18A1, SLC18A2, SLC6A3, TH |
| Amphetamine addiction | 5.97 × 10−14 | 1.40 × 10−12 | ATF6B, DRD1, GNAS, GRIA1, GRIA3, GRIA4, GRIN1, GRIN2A, GRIN2B, GRIN2D, MAOA, PDYN, PPP1R1B, PPP3CC, SLC18A1, SLC18A2, SLC6A3, STX1A, TH |
| Glutamatergic synapse | 3.52 × 10−13 | 6.61 × 10−12 | GNAO1, GNAS, GNB3, GRIA1, GRIA3, GRIA4, GRIK2, GRIK3, GRIK4, GRIN1, GRIN2A, GRIN2B, GRIN2D, GRM3, GRM4, GRM5, GRM7, GRM8, PLA2G4A, PLA2G4C, PPP3CC, SLC1A2, SLC1A6 |
| Serotonergic synapse | 2.09 × 10−12 | 3.28 × 10−11 | CACNA1F, CYP2D6, GABRB2, GNAO1, GNAS, GNB3, HTR1A, HTR2A, HTR2C, HTR3A, HTR4, HTR5A, HTR6, HTR7, MAOA, PLA2G4A, PLA2G4C, PTGS2, SLC18A1, SLC18A2, SLC6A4, TPH1 |
| Calcium signaling pathway | 4.33 × 10−12 | 5.81 × 10−11 | ADRA1A, CACNA1F, CCKAR, CD38, CHRM5, CHRNA7, DRD1, DRD5, EGFR, ERBB3, ERBB4, GNAL, GNAS, GRIN1, GRIN2A, GRIN2D, GRM5, HRH1, HRH2, HTR2A, HTR2C, HTR4, HTR5A, HTR6, HTR7, NOS1, PPP3CC |
| Nicotine addiction | 5.38 × 10−12 | 6.33 × 10−11 | CHRNA7, CHRNB2, GABRA1, GABRA6, GABRB2, GABRG2, GABRP, GRIA1, GRIA3, GRIA4, GRIN1, GRIN2A, GRIN2B, GRIN2D |
| cAMP signaling pathway | 1.66 × 10−7 | 1.73 × 10−6 | AKT1, BDNF, CACNA1F, DRD1, DRD2, DRD5, FXYD2, GABBR1, GNAS, GRIA1, GRIA3, GRIA4, GRIN1, GRIN2A, GRIN2B, GRIN2D, HTR1A, HTR4, HTR6, NPY, PDE4B, PPP1R1B |
| Alcoholism | 2.45 × 10−6 | 2.09 × 10−5 | ATF6B, BDNF, DRD1, DRD2, GNAO1, GNAS, GNB3, GRIN1, GRIN2A, GRIN2B, GRIN2D, MAOA, NPY, PDYN, PPP1R1B, SLC18A1, SLC18A2, SLC6A3, TH |
| Retrograde endocannabinoid signaling | 2.24 × 10−6 | 2.11 × 10−5 | CACNA1F, CNR1, GABRA1, GABRA6, GABRB2, GABRG2, GABRP, GNAO1, GNB3, GRIA1, GRIA3, GRIA4, GRM5, PTGS2 |
| Circadian entrainment | 6.03 × 10−6 | 4.36 × 10−5 | GNAO1, GNAS, GNB3, GRIA1, GRIA3, GRIA4, GRIN1, GRIN2A, GRIN2B, GRIN2D, NOS1, NOS1AP, PER3 |
| Rap1 signaling pathway | 8.33 × 10−5 | 4.61 × 10−4 | AKT1, CNR1, DRD2, EGF, EGFR, FGF1, FGF14, FGF18, FGFR1, GNAO1, GNAS, GRIN1, GRIN2A, GRIN2B, MAGI1, MAGI2, MAGI3, RAPGEF6 |
| Morphine addiction | 1.02 × 10−4 | 5.33 × 10−4 | DRD1, GABBR1, GABRA1, GABRA6, GABRB2, GABRG2, GABRP, GNAO1, GNAS, GNB3, PDE4B |
| MAPK signaling pathway | 1.09 × 10−4 | 5.38 × 10−4 | AKT1, BDNF, CACNA1F, EGF, EGFR, FAS, FGF1, FGF14, FGF18, FGFR1, FLNB, IL1A, IL1B, MAPK8IP2, NTF3, PLA2G4A, PLA2G4C, PPP3CC, TNF, TP53 |
| Cytokine-cytokine receptor interaction | 1.84 × 10−4 | 8.64 × 10−4 | CSF2RA, CSF2RB, CXCR1, EGF, EGFR, FAS, IL10, IL10RA, IL12B, IL18, IL18R1, IL18RAP, IL1A, IL1B, IL2, IL3, IL3RA, IL4, LTA, TNF |
| GABAergic synapse | 3.52 × 10−4 | 1.50 × 10−3 | CACNA1F, GABBR1, GABRA1, GABRA6, GABRB2, GABRG2, GABRP, GAD1, GNAO1, GNB3 |
| PI3K-Akt signaling pathway | 1.13 × 10−3 | 4.19 × 10−3 | AKT1, ATF6B, EGF, EGFR, FGF1, FGF14, FGF18, FGFR1, FN1, GNB3, GSK3B, IL2, IL3, IL3RA, IL4, PPP2R2B, RELN, TNXB, TP53, YWHAE, YWHAH, YWHAZ |
| Phospholipase D signaling pathway | 1.5 × 10−3 | 4.53 × 10−3 | AKT1, CXCR1, EGF, EGFR, GNAS, GRM3, GRM4, GRM5, GRM7, GRM8, PLA2G4A, PLA2G4C |
| ErbB signaling pathway | 1.37 × 10−3 | 4.61 × 10−3 | AKT1, EGF, EGFR, ERBB3, ERBB4, GSK3B, NRG1, NRG2, NRG3 |
| T cell receptor signaling pathway | 1.33 × 10−3 | 4.61 × 10−3 | AKT1, CD4, CTLA4, GSK3B, IL10, IL2, IL4, ITK, PPP3CC, TNF |
| Gap junction | 1.49 × 10−3 | 4.66 × 10−3 | DRD1, DRD2, EGF, EGFR, GNAS, GRM5, HTR2A, HTR2C, TUBA8 |
| Long-term depression | 2.34 × 10−3 | 6.46 × 10−3 | GNAO1, GNAS, GRIA1, GRIA3, NOS1, PLA2G4A, PLA2G4C |