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. 2018 Feb 13;8:2889. doi: 10.1038/s41598-018-21178-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Properties of liposome formulations (a) Stable formulations of particles with low polydispersity. (b) Pseudocolored ¹⁹F MRI signal of phanthoms from each formulation obtained with a ¹⁹F MSME (Excitation bandwidth = 2000 Hz, TR = 2000 ms, TE = 8.95 ms, scan time = 10 min 40 s) scan protocol. (c) Dilution studies on each formulation suggest a signal with SNR > 4 can be obtained from each at over 5 fold dilution. (d) Plot of SNR against concentration shows linearity. (e) T₁ and T₂ relaxation times for neat formulations and dilutions thereof. Data are represented as mean value ± SD.