Figure 5.

Evaluation of the spectral ¹⁹F MR imaging potential probes in an in vivo environment. (a) TurboRARE T₂ ¹H MR (same scan parameters as in Fig. 4 above) anatomy image of a isoflrane anesthetized mouse injected intramuscularly with formulations ET0876 (right thigh, position 2), and ET0890 (left thigh, position 1), and subcutaneously ET0886 (abdomen, position 3). (b) Single pulse ¹⁹F MR scan showing resonance frequencies of ¹⁹F species within the subject in the scanner with frequencies of interest highlighted by the red pointer. (c) ¹⁹F MR image obtained from a ¹⁹F MSME scan protocol (same scan parameters as in Fig. 4 above), of the selected frequency. (d) overlay of ¹⁹F MR image over anatomy image reports on location of each probe. (e) SNR of formulations in vivo (n = 4).