Table 1.
Characteriztion of liposome formulations.
| Liposome Formulation | Mean Particle Diameter (nm) | Polydispersity Index (PDI) | [Total Lipid] (mM) | [19F] (mg/mL) |
Est. Number of Particles/mL |
19F Atoms/Particle |
Plasma Leak |
|---|---|---|---|---|---|---|---|
| ET0876 | 164.8 ± 1.2 | 0.10 ± 0.04 | 142.7 ± 1.5 | 22.7 ± 1.4 | 2.0 × 1014 | 3.6 × 106 | <5% |
| ET0886 | 166.7 ± 3.6 | 0.08 ± 0.07 | 142.6 ± 1.7 | 21.9 ± 0.3 | 2.0 × 1014 | 3.5 × 106 | <5% |
| ET0890 | 166.3 ± 7.1 | 0.10 ± 0.04 | 133.1 ± 1.0 | 16.6 ± 1.7 | 1.9 × 1014 | 1.4 × 106 | <5% |
Data are represented as mean value ± SD.