Figure 7.

Negr1-deficiency impairs social behavior. (A) Three-chamber sociability test. The time spent in each chamber was determined for Negr1-WT and Negr1-KO mice (n = 20 per genotype). Negr1-KO mice interacted significantly less time with stranger mice compared to Negr1-WT mice. (B) Tube dominance test. Male mice with opposite genotype were paired for testing (n = 20 per genotype) and the number of wins and the latency to win was determined. While the number of wins was similar in both genotypes, the average latency to win was significantly shorter in Negr1-KO mice (right), indicative of altered pattern of social interaction; **p < 0.01, Student’s t-test.