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. 2018 Feb 13;8:2930. doi: 10.1038/s41598-018-19475-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Longitudinal (black) and transversal (gray) temporal diffusion spectra for ellipsoidal restrictions with longitudinal and transversal axes (a and b) estimated from EP-OGSE Monte Carlo simulations of fully dispersed samples (crosses) compared to estimates from conventional DTI OGSE of single compartments (hexagons). The EP-OGSE estimates were also estimated from noisy data with SNR = 25 using both a maximum b-value of 1.6 s/μm² and 0.6 s/μm² shown as filled dots and asterices. The latter b-value is in the range possible up to 100 Hz at a maximum gradient strength of 300 mT/m. The error bars indicate the standard deviation of each estimate. The solid lines are the analytical solutions for spheres with radii a (solid black) and b (gray dashed).