Table 4.

Intra-class correlation coefficient of the five raters of the ARIA-E imaging features in all 75 patients and in the ARIA-E cases only, averaged by all regions in each hemisphere. As is shown, the ICC of the subtraction group is slightly lower than the ICC of the native image group. The ICC score in the subtraction group of PH, SH and SW ranged from moderate to good (0.6–0.8). The combination of sulcal hyperintensity and gyral swelling resulted in an excellent agreement (a score above 0.8)

	MRI	ICC		ICC
ARIA-E imaging features		n=75	95 % CI	n=29	95 % CI
Parenchymal hyperintensity	Native	0.630	0.60-0.66	0.611	0.56-0.56
	Subtraction	0.592	0.56-0.62	0.580	0.52-0.65
Sulcal hyperintensity	Native	0.800	0.78-0.82	0.780	0.75-0.81
	Subtraction	0.745	0.72-0.77	0.721	0.66-0.77
Swelling	Native	0.683	0.66-0.71	0.634	0.58-0.69
	Subtraction	0.606	0.58-0.64	0.576	0.51-0.65
Highest score of subtypes	Native	0.912	0.89-0.93	0.810	0.73-0.87
	Subtraction	0.823	0.81-0.84	0.824	0.79-0.86
Sulcal hyperintensity and gyral swelling	Native	0.836	0.82-0.85	0.811	0.78-0.84
	Subtraction	0.815	0.80-0.83	0.805	0.76-0.84