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. 2018 Feb 13;8:2940. doi: 10.1038/s41598-018-21372-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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H3S28A mutants exhibit a prolonged median lifespan and an increased resistance to starvation and oxidative stress. (a) Median lifespan of H3S28A mutants is increased about 68% (n_H3S28S = 56, n_H3S28A = 96). (b) Median survival during acute starvation is increased about 16% in H3S28A mutants (n_H3S28S = 101, n_H3S28A = 152; 7–10 days old). (c) Median survival during acute exposure to 15 mM paraquat is increased about 20% in H3S28A mutants (n_H3S28S = 70, n_H3S28A = 88; 7–10 days old). Each curve represents the average of at least 3 separate experiments.