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. 2018 Feb 13;8:2952. doi: 10.1038/s41598-018-21087-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Vascular remodeling and function in arteries from db/db versus db/+ mice. (A) NE-induced contraction of mesenteric resistance arteries from control db/+ and db/db mice, treated by an MR antagonist (30 mg/kg/day, 4 weeks) or vehicle (saline), was performed using a wire myograph. Increased NE-induced contractility in db/db mice was prevented by canrenoate treatment. Structural and mechanical parameters were assessed by pressurized myography in mesenteric arteries from db/db vs db/+ mice. Vascular wall to lumen ratio (B) and CSA (C) were increased in db/db mice. (D) The stress-strain relationship was shifted to the left indicating that vascular stiffness is increased in db/db vs db/+ mice. All of these vascular changes were prevented by canrenoate treatment. Results are expressed mean ± SEM, n = 6–8 mice/group, *p < 0.05 db/db vs db/+, ^†p < 0.05 vehicle vs +MRA. CSA: cross sectional area; MRA: MR antagonist (canrenoate). Vehicle: saline NaCl 0.9%.