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. 2018 Feb 13;8:2952. doi: 10.1038/s41598-018-21087-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Pro-fibrotic and pro-inflammatory markers mRNA levels in arteries from db/db and db/+ mice. (A) Pro-fibrotic markers such as Col1a, Col3a and Tgfb1 mRNA levels were increased in mesenteric arteries from db/db compared to db/+ mice. (B) Pro-inflammatory markers such as IL-6, Tnfa and Mcp-1 mRNA levels were increased in mesenteric arteries from db/db compared to db/+ mice. Ubc was used as housekeeping gene for normalization. Results are expressed mean ± SEM, n = 6–8 mice per group, *p < 0.05, **p < 0.01 db/db vs db/+, ^†p < 0.05 vehicle vs +MRA. Vehicle: saline NaCl 0.9%. IL-6: interleukine-6; Mcp-1: monocyte chemoattractant protein 1; Tnfα: tumor necrosis factor alpha; Tgfβ1: transforming growth factor beta 1; Ubc: ubiquitin C.