Table 1.
Haematological and bone marrow values after Epo‐LFM‐A13‐therapy
| DLD‐1 xenografts | HT‐29 xenografts | |||
|---|---|---|---|---|
| Con | Epo + LFM | Con | Epo + LFM | |
| WBC (103 mm−3) | 1.8 (1.4–2.2) | 2.2 (1.8–4)* | 3.5 (2.4–6) | 3.3 (2.3–5.3) |
| RBC (106 mm−3) | 8.9 (8.29–9.61) | 11.4 (11–12.2)* | 8.43 (8.17–11.7) | 10.7 (8.6–12.7)* |
| HGB (g·L−1) | 149 (142–157) | 205 (163–212)* | 150 (143–212) | 190 (151–204)* |
| HCT (%) | 45.1 ± 2.98 | 65.0 ± 2.39* | 42 ± 0.69 | 56.9 ± 7.1* |
| PLT (103 mm−3) | 890.7 ± 57.1 | 746.0 ± 73.6* | 782.4 ± 127.1 | 702.9 ± 30.7 |
| MCV (μm3) | 50 (50–53) | 56.5 (54–58)* | 50.5 (48–53) | 53.5 (50–57)* |
| MCH (pg) | 17 ± 0.31 | 17.8 ± 0.6* | 17.5 ± 0.65 | 17.5 ± 0.85 |
| MCHC (g·L−1) | 316 (308–320) | 340 (322–345)* | 324 (319–348) | 351 (319–358) |
| Proerythroblasts (%) | 0.6 (0–2.2) | 1.5 (0.4–3.6) | 2.3 (1–4) | 2.4 (1–3.4) |
| Basophilic erythroblast (%) | 6.6 (4–10.2) | 5.2 (2.6–8.2) | 5 (4–7.4) | 1.8 (0.8–4)* , # |
| Polychromatic erythroblast (%) | 6.4 (4.2–8.6) | 6.1 (2.2–9.4) | 9 (5.4–12) | 6 (4–8) |
| Orthochromatic erythroblast (%) | 2.8 (2–3.2) | 1.4 (0.4–3) | 5.4 (4.4–8) | 4.4 (4–5.4)# |
| Myeloblast (%) | 0.2 (0–1.6) | 0.2 (0–2) | 0.3 (0–1.2) | 1 (0.6–1.6) |
| Promyelocyte (%) | 1.6 (1.4–3.2) | 3.8 (2.4–5)* | 4.3 (3.4–9) | 3.4 (1.2–6) |
| Neutrophilic myelocyte (%) | 19.2 (14.2–22.2) | 23.6 (21.4–25.2) | 19.2 (18.2–19.6) | 22.4 (19.4–24.2)* |
| Neutrophilic metamyelocyte (%) | 18.4 (15.4–19.8) | 19.4 (17–21) | 14.8 (11.6–16.4) | 16.6 (12.4–21.6) |
| Neutrophilic band (%) | 15 (14.6–20.6) | 17.7 (15.2–19.4) | 15.7 (14.8–17.6) | 15.6 (13.2–18) |
| Neutrophil segmend (%) | 17 (7.8–30.8) | 14 (8.8–19) | 16.4 (13.2–19.4) | 15.2 (13–18.4) |
| Megacariocyte (%) | 0.6 (0.4–1) | 1.3 (0.4–2.4) | 1.3 (0.6–2.4) | 1 (0.4–2.6) |
| Lymphocyte (%) | 3.8 (3.2–4) | 2.9 (2–4) | 2 (1.4–2.6) | 2.8 (1.4–5.8) |
| Monocyte (%) | 0.4 (0.2–0.4) | 1.2 (0–1.8) | 0.8 (0.4–1.2) | 1.2 (0–2.4) |
The results are presented as mean values ± SD or median (minimum – maximum), n = 7–8;
*
P < 0.05 (vs. Con),
#
P < 0.05 (DLD‐1 vs. HT‐29).