Figure 5.

AT‐403 attenuated the expression of L‐DOPA‐induced dyskinesia. ALO AIMs were scored in 6‐OHDA hemi‐lesioned dyskinetic rats following challenge with L‐DOPA (6 mg·kg⁻¹ plus benserazide 12 mg·kg⁻¹, s.c., n = 16) combined with vehicle (s.c., n = 16), AT‐403 0.03 mg·kg⁻¹ (s.c., n = 15; one data point was discarded as the animal did not respond to L‐DOPA) or AT‐403 0.1 mg·kg⁻¹ (s.c., n = 16). Data (means ± SEM) are expressed as ALO AIMs score for each time point in absolute values (A) or as separate ALO AIMs scores over the 3 h observation period (i.e. cumulative scores calculated as the sum of scores at each time point; B). On a separate day, treatments were replicated in the same animals, and rotarod performance (time on rod in seconds, n = 10 determinations per group) was evaluated before and 60 min after drug administration (C). *P < 0.05, significantly different from vehicle. #P < 0.05, different from vehicle ON L‐DOPA. Statistical analysis was performed by two‐way RM (A) or two‐way (C) ANOVA followed by the Bonferroni test for multiple comparisons or one‐way ANOVA followed by the Newman–Keuls test for multiple comparisons (B).