Figure 6.

AT‐390 delayed and prolonged the expression of L‐DOPA‐induced dyskinesia. ALO AIMs were scored in 6‐OHDA hemi‐lesioned dyskinetic rats following challenge with L‐DOPA (6 mg·kg⁻¹ plus benserazide 12 mg·kg⁻¹, s.c.) combined with vehicle or AT‐390 (0.3 or 1 mg·kg⁻¹, s.c., n = 8 determinations per group). The effect of AT‐390 3 mg·kg⁻¹ was evaluated separately in a small number of rats (n = 4). Data (means ± SEM) are expressed as ALO AIMs score for each time point in absolute values (A, C) or as separate ALO AIMs scores over the 3 h observation period (i.e. cumulative scores calculated as the sum of scores at each time point; B). On a separate day, treatments were replicated in the same animals, and rotarod performance was evaluated (as time on rod in seconds; n = 6 determinations per group) before and 60 min after drug administration (D). *P < 0.05, significantly different from L‐DOPA + vehicle. Statistical analysis was performed by two‐way RM (A) or two‐way (D) ANOVA followed by the Bonferroni test for multiple comparisons or one‐way ANOVA followed by the Newman–Keuls test for multiple comparisons (B).