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. 2018 Jan 25;175(5):830–839. doi: 10.1111/bph.14128

Figure 4.

Figure 4

A54 inhibits EA‐evoked current in TRPC5 channels. (A) Example of whole‐cell patch‐clamp data from a TRPC5‐expressing HEK 293 cell showing current sampled at −100 and +100 mV during ramp changes in voltages (all agents were bath applied). EA 10 nM and 1 μM A54 were used. Vehicle (Veh.) was DMSO. Wash indicates washout of EA and A54. (B) Representative current–voltage relationship (I–V) from experiments of the type illustrated in (A). (C, D) Mean percentage inhibition of responses to A54 as illustrated in (A) for (C) +100 mV and (D) −100 mV (n = 5 independent recordings).