Figure 5.

A54 enhances Gd³⁺‐evoked current in TRPC5 channels. (A) Example of whole‐cell patch‐clamp data from a TRPC5‐expressing HEK 293 cell showing current sampled at −100 and +100 mV during ramp changes in voltages (all agents were bath‐applied). Gd³⁺ μM and 1 μM A54 were used. Wash indicates washout of Gd³⁺ and A54. (B) Representative current–voltage relationship (I–V) from experiments of the type illustrated in (A). (C, D) Mean percentage enhancement of responses to A54 as illustrated in (A) for (C) +100 mV and (D) −100 mV (n = 5 independent recordings). Veh., vehicle.