. 2018 Jan 10;236(3):R161–R167. doi: 10.1530/JOE-17-0560
This work is licensed under a Table 1.
Genes implicated in the tumorigenesis of pancreatic neuroendocrine tumours (PanNETs) before the publication of the International Cancer Genome Consortium data.
| Gene/locus | First information source | Pathway |
|---|---|---|
| MEN1 | Genetic syndrome (multiple endocrine neoplasia type I) | Chromatin remodeling, altered telomeres, PI3K/mTOR DNA double-strand break repair |
| VHL | Genetic syndrome (Von-Hippel Lindau) | PI3K/mTOR |
| NF1 | Genetic syndrome (neurofibromatosis type I) | PI3K/mTOR, Ras/MAPK |
| TSC1/TSC2 | Genetic syndrome (tuberous sclerosis) | PI3K/mTOR |
| PTEN | Next-generation sequencing of PanNETs | PI3K/mTOR |
| ATRX | Next-generation sequencing of PanNETs | Telomeres elongation |
| DAXX | Next-generation sequencing of PanNETs | Telomeres elongation, PI3K/mTOR |
| 1q, 3p, 6q, 10q, 11q | Chromosomal abherrations of PanNETs (LOSS) | – |
| 7p, 9p, 17q, 20q | Chromosomal abherrations of PanNETs (GAIN) | – |
| RASSF1A | Promoter hypermethylation in PanNETs | Ras/MAPK |
| CDKN2A | Promoter hypermethylation in PanNETs | Cell cycle |
| ALU, LINE1 | Promoter hypomethylation in PanNETs | – |
| miR-21 | miRNA differential expression in PanNETs | PI3K/mTOR |