Table 4. Multivariate analysis of overall survival in high-grade osteosarcoma with inclusion of class I histone deacetylase expression.
| Factor |
Overall survival |
|
|---|---|---|
| HR (95% CI) | P-value | |
| Age at diagnosis, years | ||
| ≤15 | 1.00 | — |
| >15 | 0.91 (0.50–1.67) | 0.771 |
| Gender | ||
| Male | 1.00 | — |
| Female | 0.73 (0.39–1.36) | 0.321 |
| Site | ||
| Extremities | 1.00 | — |
| Axial | 3.12 (1.30–7.52) | 0.011 |
| Tumor size | ||
| ≤10 cm | 1.00 | — |
| >10 cm | 1.70 (0.88–3.25) | 0.112 |
| Histone deacetylases | ||
| Group1a: Not all low | 1.00 | — |
| Group2b: All low | 1.96 (1.04–3.73) | 0.039 |
P-values<0.05 were shown in bold.
a
Group1—none or some histone deacetylase isoforms expressed at immunoreactive score lower than the cutoff.
b
Group2—all-histone deacetylase isoforms expressed at immunoreactive score lower than the cutoff.