Table 6. Multivariate analysis of overall survival in stage IIB osteosarcoma with inclusion of class I histone deacetylase expression.
| Factor |
Overall survival |
|
|---|---|---|
| HR (95% CI) | P-value | |
| Age at diagnosis, years | ||
| ≤15 | 1.00 | — |
| >15 | 1.47 (0.56–3.90) | 0.436 |
| Gender | ||
| Male | 1.00 | — |
| Female | 0.93 (0.33–2.67) | 0.898 |
| Site | ||
| Extremities | 1.00 | — |
| Axial | 6.34 (1.55–26.04) | 0.010 |
| Tumor size | ||
| ≤10 cm | 1.00 | — |
| >10 cm | 0.86 (0.27–2.70) | 0.791 |
| Histone deacetylases | ||
| Group1a: Not all low | 1.00 | — |
| Group2b: All low | 3.44 (1.07–11.09) | 0.038 |
P-values <0.05 were shown in bold.
a
Group1—none or some histone deacetylase isoforms expressed at immunoreactive score lower than the cutoff.
b
Group2—all-histone deacetylase isoforms expressed at immunoreactive score lower than the cutoff.