Table 1.
Baseline characteristics of the retrospective and prospective cohorts.
| Characteristic | Training cohort (N=823,627) n (%) |
Validation cohort (N=680,810) n (%) |
|
| Age (years) |
|
|
|
|
|
<35 | 389,081 (47.23) | 403,932 (59.30) |
|
|
35-49 | 202,906 (24.64) | 158,580 (23.29) |
|
|
50-64 | 118,624 (14.40) | 71,687 (10.53) |
|
|
≥65 | 112,709 (13.68) | 46,611 (6.85) |
| Gender |
|
|
|
|
|
Male | 366,859 (44.54) | 294,430 (43.25) |
|
|
Female | 456,768 (55.46) | 386,380 (56.75) |
| Race |
|
|
|
|
|
White | 781,457 (94.88) | 634,107 (93.14) |
|
|
Black | 9060 (1.11) | 10,212 (1.50) |
|
|
Asian | 8978 (1.09) | 6332 (0.93) |
|
|
Other | 24,050 (2.92) | 30,159 (4.43) |
| Diagnostic disease |
|
|
|
|
|
Cardiovascular diseases | 50,769 (6.16) | 26,259 (3.86) |
|
|
Disorders of lipid metabolism | 22,223 (2.70) | 22,063 (3.24) |
|
|
Type 2 diabetes | 23,464 (2.85) | 17,999 (2.64) |
|
|
COPDa | 8391 (1.02) | 8534 (1.25) |
|
|
Acquired hemolytic anemia | 6508 (0.79) | 6289 (0.92) |
|
|
Liver disorders | 6194 (0.75) | 4121 (0.61) |
|
|
Idiopathic hypersomnia | 5141 (0.62) | 2991 (0.44) |
|
|
Prehypertension | 2439 (0.30) | 1877 (0.28) |
|
|
Chronic nephritis | 3055 (0.37) | 1713 (0.25) |
|
|
Chronic kidney disease | 2389 (0.29) | 1404 (0.21) |
|
|
Hypopotassemia | 1245 (0.15) | 765 (0.11) |
|
|
Hyposmolality or hyponatremia | 549 (0.07) | 381 (0.06) |
|
|
Diagnosed as primary hypertension after 1 year | 92,512 (11.23) | 60,065 (8.82) |
aCOPD: chronic obstructive pulmonary disease.