Table 3.
Effects of the test materials on circular excision wound model
| Material | Extract type | Wound area (mm2) ± SEM (Contraction%) | |||||
|---|---|---|---|---|---|---|---|
| Day 0 | Day 2 | Day 4 | Day 6 | Day 8 | Day 10 | ||
| Vehicle | 20.25±3.24 | 18.32±2.45 (2.86) | 15.49±2.08 (3.61) | 10.24±1.69 (9.70) | 6.56±1.89 (7.48) | 4.10±0.47 (6.18) | |
| Negative Control | 21.16±3.31 | 18.86±2.78 | 16.07±2.16 | 11.34±1.79 | 7.09±0.91 | 4.37±0.66 | |
| T. argenteum subsp. argenteum | CHCl3 | 22.24±3.83 | 15.52±1.68 (15.28) | 12.29±1.84 (20.66) | 7.71±1.92 (24.71) | 3.86±0.69 (41.16)* | 1.11±0.55 (72.93)*** |
| MeOH:H2O | 20.75±2.54 | 16.92±1.95 (7.64) | 13.88±1.99 (10.39) | 8.91±1.36 (12.98) | 5.45±0.99 (16.92) | 3.49±0.70 (14.88) | |
| T. heterotomum | CHCl3 | 21.19±3.04 | 15.98±1.75 (12.77) | 13.13±1.92 (15.24) | 8.35±1.86 (18.45) | 4.64±0.75 (29.26) | 2.81±0.39 (21.71) |
| MeOH:H2O | 19.96±3.15 | 18.42±2.25 - | 14.04±2.22 (9.36) | 8.91±1.74 (12.99) | 5.54±0.91 (15.54) | 3.03±0.52 (26.09) | |
| T. densum subsp. sivasicum | CHCl3 | 21.47±2.99 | 15.56±1.93 (15.07) | 12.08±1.79 (22.01) | 7.11±1.33 (30.57)* | 2.55±0.81 (61.13)** | 0.49±0.48 (88.05)*** |
| MeOH:H2O | 20.68±2.90 | 17.31±2.10 (5.51) | 14.50±2.09 (6.39) | 8.99±1.50 (12.21) | 5.73±0.91 (12.65) | 1.76±0.61 (8.29) | |
| T. vulgare | CHCl3 | 21.55±3.31 | 17.91±2.07 (2.23) | 14.32±2.11 (7.55) | 8.45±2.01 (17.48) | 4.02±1.10 (38.71)* | 2.26±0.43 (44.88)* |
| MeOH:H2O | 20.52±3.41 | 15.77±2.17 (13.91) | 13.38±2.07 (13.62) | 8.49±1.70 (17.08) | 4.98±0.98 (24.08) | 2.66±0.59 (22.92) | |
| Madecassol® | 20.44±2.67 | 15.07±1.91 (17.74) | 11.27±1.71 (27.24) | 5.29±1.12 (48.34)* | 2.01±0.32 (69.36)** | 0.00±0.00 (100.00)*** | |
*
: P<0.05;
**
: P<0.01;
***
: P<0.001;
SEM: Standard error of the mean; percentage of the tensile strength values: The vehicle group was compared to the negative control group; The test materials and the reference material were compared to vehicle group