Table 1.
Significant changes (down‐ or upregulated) in expression of osteogenesis‐relevant genes of ASCs incubated with osteogenic standard medium (ASCOM)
| Fold | Regulation | Gene description/gene symbol |
|---|---|---|
| 1,69 | down | ADAM metallopeptidase with thrombospondin type‐1 motif‐20/ADAMTS20 |
| 4,87 | down | ADAM metallopeptidase with thrombospondin type‐1 motif‐6/ADAMTS6 |
| 2,35 | down | ADAM TS‐like protein 5/LOC100512586 |
| 3,48 | down | BMP‐binding endothelial regulator/BMPER |
| 2,34 | down | Catenin (cadherin‐associated protein) alpha‐1/CTNNAL1 |
| 3,06 | down | Chemokine (C‐X‐C motif) ligand 2/CXCL2 |
| 1,64 | down | Chemokine (C‐X‐C motif) receptor 7/CXCR7 |
| 4,69 | down | Cyclic AMP‐dependent transcription factor ATF‐3/LOC100738612 |
| 1,40 | down | Cyclin‐dependent kinase1/CDK1 |
| 1,37 | down | Cyclin‐dependent kinase 6/CDK6 |
| 3,40 | down | Cyclin‐dependent kinase inhibitor 3/CDKN3 |
| 1,55 | down | Fibroblast growth factor 19/LOC100518950 |
| 1,82 | down | Inositolpolyphosphate‐5‐phosphatase/INPP5B |
| 2,37 | down | Insulin‐like growth factor binding protein 4/IGFBP4 |
| 3,69 | down | Insulin‐like growth factor binding protein 6/IGFBP6 |
| 9,60 | down | Interleukin‐33/LOC100518643 |
| 23,72 | down | Interleukin‐6/IL6 |
| 1,99 | down | Mitogen‐activated protein kinase 8/LOC100622217 |
| 9,67 | down | Protein kinase (cAMP‐dependent, catalytic) inhibitor alpha/PKIA |
| 2,36 | down | Sestrin‐2/LOC100620966 |
| 3,21 | down | Toll‐like receptor 3/TLR3 |
| 1,57 | down | Wntless homologue/WLS |
| 1,48 | up | ADAM metallopeptidase domain 10/ADAM10 |
| 2,51 | up | ADAM metallopeptidase domain 19/ADAM19 |
| 2,97 | up | ADAM metallopeptidase with thrombospondin type‐1 motif‐1/ADAMTS1 |
| 2,14 | up | ADAM metallopeptidase with thrombospondin type‐1 motif‐12/ADAMTS12 |
| 1,43 | up | Bone morphogenetic protein 1/BMP1 |
| 1,33 | up | Bone morphogenetic protein 2/BMP2 |
| 1,52 | up | cAMP‐responsive element binding protein 3‐like‐4/CREB3L4 |
| 2,60 | up | Catalase/CAT |
| 1,93 | up | Cathepsin F/CTSF |
| 1,52 | up | Cathepsin Z/CTSZ |
| 1,82 | up | CCAAT/enhancer‐binding protein delta/LOC100153946 |
| 1,44 | up | CCAAT/enhancer‐binding protein delta/LOC100621023 |
| 1,57 | up | CCAAT/enhancer‐binding protein(C/EBP) beta|/CEBPB |
| 2,62 | up | Collagen, type IV, alpha 2/COL4A2 |
| 1,58 | up | Collagen, type IV, alpha 5/LOC100737091 |
| 1,51 | up | Collagen, type V, alpha 3/COL5A3 |
| 2,61 | up | Collagen and calcium‐binding EGF domain‐containing protein1/LOC100510995 |
| 7,13 | up | Complement component 7/C7 |
| 14,66 | up | Complement component C9/LOC100037951 |
| 1,53 | up | CREB‐binding protein/LOC100738967 |
| 2,57 | up | Cyclin‐dependent kinase‐5/CDKL5 |
| 1,55 | up | Cyclin‐dependent kinase 19/CDK19 |
| 2,46 | up | Cyclin‐dependent kinase 9/CDK9 |
| 1,51 | up | F‐box and leucine‐rich repeat protein 5/FBXL5 |
| 1,64 | up | F‐box protein 21/FBXO21 |
| 2,05 | up | Forkhead box O1/FOXO1 |
| 3,02 | up | Forkhead box O3/FOXO3 |
| 1,86 | up | Homeobox A5/HOXA5 |
| 2,79 | up | Homeobox protein cut‐like2/LOC100153673 |
| 1,60 | up | Homeobox protein Hox‐A6/LOC100519284 |
| 1,98 | up | Homeodomain interacting protein kinase 3/LOC100738110 |
| 9,39 | up | Insulin‐like growth factor binding protein 3/IGFBP3 |
| 2,12 | up | Insulin receptor/INSR |
| 1,56 | up | Interleukin‐18 receptor alpha chain/IL‐18RA |
| 1,65 | up | Interleukin‐1 receptor‐associated kinase‐2/LOC100523467 |
| 2,45 | up | Interleukin‐1 receptor type 1/LOC100626904 |
| 2,42 | up | Interleukin‐1 receptor type 2/IL1R2 |
| 2,02 | up | Interleukin‐6 receptor/IL6R |
| 1,73 | up | Janus kinase 1/JAK1 |
| 1,47 | up | MAP kinase‐activated protein kinase 2/MAPKAPK2 |
| 1,85 | up | Mitogen‐activated protein kinase 3/MAP3K3 |
| 3,22 | up | SH2 domain‐containing protein 4A/LOC100518097 |
| 1,64 | up | SH3 and PX domains 2A/SH3PXD2A |
| 2,20 | up | Transforming growth factor beta‐1/TGFBI |
| 1,44 | up | Transforming growth factor beta‐1 receptor 1/TGFBR1 |
| 1,87 | up | WNT1 inducible signalling pathway protein 1/WISP1 |
| 3,88 | up | Wnt‐16/LOC100511484 |