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. 2016 Nov 16;23(1):90–101. doi: 10.1111/adb.12476

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© 2016 The Authors.Addiction Biology published by John Wiley & Sons Ltd on behalf of Society for the Study of Addiction

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Concurrent methamphetamine (MA) self‐administration decreases alcohol preference and consumption but not total consumption. (a) Average daily alcohol preference during pre‐MA baseline, MA co‐use and post‐MA extinction phases are shown for the 10 percent ethanol group in Experiment 1. Average preference during the MA co‐use phase (40.8 ± 2.2 percent; indicated by rose shading) was significantly reduced compared with both pre‐MA baseline (60.5 ± 3.7 percent) and post‐MA extinction (70.1 ± 5.3 percent). (b) Average daily alcohol intake during pre‐MA baseline, MA co‐use and post‐MA extinction phases are shown for the 10 percent ethanol group in Experiment 1. Average intake during the MA co‐use phase (2.36 ± 0.1 g/kg/day; indicated by rose shading) was significantly reduced compared with both pre‐MA baseline (3.94 ± 0.3 g/kg/day) and post‐MA extinction (4.00 ± 0.3 g/kg/day). (c) Total fluid consumption during the three phases was not altered. * Significant from pre‐MA baseline and post‐MA extinction (p < 0.001)