Table 1.
Description of 18 Selected Proteins
| Protein | Uniprot # | Gene Ontology Biological Process | Pathway |
|---|---|---|---|
| ON (SPARC) | P09486 | Cellular response to growth factor stimulus, ECM organization, heart development, lung development, negative regulation of angiogenesis | ECM proteoglycans |
| STK16 | O75716 | Cellular response to transforming growth factor β stimulus | |
| SCGF-α | Q9Y240 | Positive regulation of cell proliferation | |
| Endocan | Q9NQ30 | Angiogenesis, positive regulation of cell proliferation | |
| NCK1 (cytoplasmic protein) | P16333 | Translation regulation | VEGFA–VEGFR2 pathway |
| Survivin | O15392 | Apoptosis, transcription regulation | Mitotic prometaphase |
| PDGF-AA | P04085 | Developmental protein, growth factor | Non-integrin membrane–ECM interactions |
| PDGF-BB | P01127 | Developmental protein, growth factor | Non-integrin membrane–ECM interactions |
| MMP7 | P09237 | Collagen degradation | Degradation of the ECM, activation of matrix metalloproteinases |
| PDE5A | O76074 | Negative regulation of cardiac muscle contraction, positive regulation of cardiac muscle hypertrophy, relaxation of cardiac muscle | cGMP effects |
| APP | P05067 | Heparin binding, protease inhibitor, serine protease inhibitor | ECM proteoglycans |
| PF-4 | P02776 | Cytokine, heparin binding | Cell surface interactions at the vascular wall |
| SCGF-β | Q9Y240 | Positive regulation of cell proliferation | |
| GP114 | Q8IZF4 | Cell surface receptor signaling pathway | |
| TIMP-3 | P35625 | Sensory transduction | Platelet degranulation |
| MSPR | Q04912 | Immunity, innate immunity | Signaling by MST1 |
| MSP | P26927 | Hepatocyte growth factor receptor signaling pathway, negative regulation of gluconeogenesis, regulation of cAMP-dependent protein kinase activity | Signaling by MST1 |
| Bone proteoglycan ll | P07585 | Cytokine-mediated signaling pathway, negative regulation of angiogenesis, negative regulation of vascular endothelial growth factor signaling pathway | Degradation of the ECM, ECM proteoglycans |
Definition of abbreviations: APP = amyloid precursor protein; cGMP = cyclic guanosine monophosphate; ECM = extracellular matrix; GP114 = G-protein–coupled receptor 114; MMP7 = matrix metalloproteinase-7; MSP = macrophage-stimulating protein; MSPR = macrophage-stimulating protein receptor; MST1 = macrophage stimulating 1; NCK1 = noncatalytic region of tyrosine kinase adaptor protein 1; ON = osteonectin; PDGF = platelet-derived growth factor; PDE5A = phosphodiesterase 5A; PF4 = platelet factor 4; SCGF = stem cell growth factor; SPARC = secreted protein acidic and rich in cysteine; STK16 = serine/threonine-protein kinase 16; TIMP3 = tissue inhibitor of metalloproteinases 3; VEGFA = vascular endothelial growth factor A; VEGFR2 = vascular endothelial growth factor receptor 2.