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. Author manuscript; available in PMC: 2018 Feb 14.
Published in final edited form as: Acta Physiol (Oxf). 2015 Nov 5;216(1):90–100. doi: 10.1111/apha.12614

Figure 2.

Figure 2

Protein sequence similarities between dopamine D1 and D2 receptors and serotonin receptors. Protein sequence alignments were performed between 5HT-2A and 2C serotonin receptors and dopamine receptors D1 and D2. (a) is a diagram of protein regions analyzed, including three extracellular regions (extracellular loop 1, extracellular loop 2, extracellular loop 3) of D2R. (b) shows residues analysed in each extracellular loop (1, 2 and 3). Identical residues are indicated in bold and highlighted (grey). Protein sequence alignments were performed using the basic local alignment search tool analysis program (BLAST) (National Center for Biotechnology Information) and WUR MUSCLE multiple alignment analysis program (www.bioinformatics.nl/tools/muscle.html).