Table 4.
Associations of asthma status determined by NLP and manual chart review with known risk factors for asthma (construct validity)
| By NLP | By manual chart review | |||||||
|---|---|---|---|---|---|---|---|---|
| No asthma (n = 392) | Asthma (n = 35) | ORd (95% CI) |
p-value | No asthma (n = 391) | Asthma (n = 36) | ORd (95% CI) |
p-value | |
| Age,a years, median (IQR) | 5.2 (3.4, 6.7) |
6.2 (4.6, 6.8) |
1.2 (1.0, 1.4) |
.01 | 5.1 (3.5, 6.7) |
6.3 (4.4, 6.8) |
1.2 (1.0, 1.4) |
.02 |
| Male, n (%) | 188 (47%) | 21 (60%) |
1.6 (0.8, 3.2) |
.17 | 188 (48%) | 21 (58%) |
1.5 (0.7, 3.0) |
.23 |
| White, n (%) | 290 (75%) | 25 (71%) |
0.8 (0.3, 1.7) |
.62 | 288 (75%) | 27 (75%) |
1.0 (0.4, 2.2) |
.97 |
| Birth weight, median (IQR) | 3.14 (2.5,3.5) | 2.8 (2.3,3.4) | 0.9 (0.9, 1.0) |
.08 | 3.1 (2.5–3.5) |
2.8 (2.4–3.4) |
0.9 (0.9, 1.0) |
.14 |
| Cesarean section, n(%) | 115 (29%) | 11 (31%) |
1.1 (0.5,2.3) | .79 | 116 (30%) | 10 (28%) |
0.9 (0.4–1.9) |
.81 |
| Gestational age, median (IQR) | 37 (36,39) | 36 (36,37) | 0.8 (0.6, 1.0) |
.07 | 37 (36,39) | 36 (36,38) | 0.8 (0.7, 1.0) |
.15 |
| Allergic rhinitis, n (%) | 31 (8%) |
8 (23%) |
3.4 (1.4, 8.2) |
< .01 | 31 (8%) |
8 (22%) |
3.3 (1.3, 7.8) |
< .01 |
| Eczema, n (%) | 87 (22%) |
15 (44%) |
2.7 (1.3, 5.6) |
< .01 | 86 (22%) |
16 (44%) |
2.8 (1.3, 5.6) |
< .01 |
| Family history of asthma, n (%) | 80 (20%) |
21 (60%) |
5.8 (2.8, 12.0) |
< .01 | 80 (20%) |
21 (58%) |
5.4 (2.6,11.0) | < .01 |
| Family history of atopic diseases, n(%) | 150 (38%) | 14 (40%) |
1.0 (0.5–2.1) |
.83 | 148 (37%) | 16 (44%) |
1.3 (0.6–2.6) |
.43 |
| Passive smoke exposure, n (%) | 51 (14%) | 8 (24%) | 1.9 (0.8–4.5) |
.11 | 51 (14%) |
8 (24%) |
1.8 (0.8–4.3) |
.13 |
| Maternal smoking,bn (%) | 25 (6%) |
8 (23%) |
4.4 (1.8, 10.7) |
< .01 | 25 (7%) |
8 (23%) |
4.2 (1.7,10.3) | < .01 |
| Childcare attendance,cn (%) | 165 (42%) | 18 (51%) |
1.4 (0.7, 2.9) |
.28 | 164 (42%) | 19 (53%) |
1.5 (0.7, 3.0) |
.21 |
| Breastfeeding, n (%) | 327 (85%) | 27 (82%) |
0.8 (0.3, 2.0) |
.66 | 325 (84%) | 29 (85%) |
1.0 (0.3, 2.8) |
.89 |
aAge at the last follow-up date
bmaternal smoking status during pregnancy
cChildcare attendance before 3 years
dUnadjusted Odds ratio