Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Feb 13;18:20. doi: 10.1186/s12935-018-0519-x

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

PMC Copyright notice

Fig. 4 — Bioinformatics analyze of RRS1 knock-down cells revealed dramatic alterations of transcriptome in the thyroid cancer cells. a Dot plots of gene ontology terms enriched on RRS1 knock-down upregulated genes (top panel, red) and downregulated genes (bottom panel, blue) were shown in dots scaled by − log10 (P). b Example gene set enrichment analysis of genes altered in RRS1 knock-downs. Top panel: Ribosome related genes had a significant negative normalized enrichment score (NES) upon RRS1 knock-down. Middle-up panel: HES/HEY pathway related genes had a significant NES upon RRS1 knock-down. Middle-down panel: MEF2D pathway related genes had a significant NES upon RRS1 knock-down. Bottom panel: Glycan degradation gene set had a significant positive NES upon knock-down of RRS1. c Summary of microarray assay by multiple bioinformatics tool