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. 2018 Feb 13;19:7. doi: 10.1186/s40360-018-0197-2

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© The Author(s). 2018

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Tomatidine (a) is a steroid alkaloid structurally characterized by 6 rings, 12 stereogenic centers, a 3 β-hydroxyl group and spiro-fused E, F rings in the form of an aminoketal. The tomatidine analog, FC04–100 (b) contains a diamine in position 3 of ring A