. 2018 Feb 14;7:12. doi: 10.1186/s40249-018-0389-4

Table 3.

Sensitivity analysis on the impact of the number of visits at the treatment centre on average cost per patient and on the impact of productivity loss on average cost per patient

	Av. days open CL ulcer	Av. cost per patient	Av. direct non-medical cost per patient		NMB (WTP = 1.92)	INMB (WTP = 1.92)
	Av. days open CL ulcer	Av. cost per patient	% of av. cost	Abs. value	NMB (WTP = 1.92)	Group II: 6 visits	Group II: 12 visits	Group III: 6 visits	Group III: 12 visits
Group I
6 visits at treatment centre	174	10.13	27	2.71	238	90	86	29	25
9 visits at treatment centre	174	11.43	36	4.07	236	92	88	31	27
12 visits at treatment centre	174	12.50	43	5.42	235	93	89	32	28
Group II^a
6 visits at treatment centre	126	11.82	35	4.09	328	0	−4	−61	−65
9 visits at treatment centre	126	13.87	44	6.14	326	2	−2	−59	−63
12 visits at treatment centre	126	15.91	51	8.18	324	4	0	−57	−61
23 visits at treatment centre	126	23.42	67	15.69	316	12	8	− 49	−53
Group III^a
6 visits at treatment centre	156	14.88	24	3.56	267	61	57	0	−4
9 visits at treatment centre	156	16.66	32	5.34	265	63	59	2	−2
12 visits at treatment centre	156	18.44	39	7.12	263	65	61	4	0
23 visits at treatment centre	156	24.97	55	13.65	257	71	67	10	6
	Av. days open CL ulcer	Av. cost per patient	Av. indirect cost per patient		NMB (WTP = 1.92)	INMB (WTP = 1.92)
	Av. days open CL ulcer	Av. cost per patient	% of av. cost	Abs. value	NMB (WTP = 1.92)	Group I: 1% prod. Loss	Group I: 10% prod. Loss	Group I: 20% prod. Loss
Group I
1% productivity loss	174	11.43	28.96	3.31	236	–	30	63
10% productivity loss	174	41.19	80.38	33.11	207	−30	–	−33
20% productivity loss	174	74.26	89.17	66.22	174	−63	−33	–
Group II
1% productivity loss	126	15.91	14.59	2.32	324	88	118	151
10% productivity loss	126	36.60	62.79	22.98	304	67	97	130
20% productivity loss	126	59.58	77.16	45.97	281	44	74	107
Group III
1% productivity loss	156	24.97	11.62	2.90	257	20	50	83
10% productivity loss	156	51.10	57.73	29.50	231	−6	24	57
20% productivity loss	156	80.12	72.50	58.09	202	−35	−5	28

^a No changes have been made to the treatment protocol in each regimen, only the number of visits to the centre have been varied. Dressing changes can be done by the patient himself, visits at the centre can be reduced to a minimum check of the wound healing process. In Group I, 6 visits correspond to the WHO protocol, 6 visits to the average of visits including non-compliant patients, and 12 visits to the foreseen RCT protocol for IL SSG injections