Fig. 4.

Gene context and LD map of the bovine chromosome 23 containing the SNPs significantly associated in the GWAS. A) BTA23:24,872,758–29,535,762 bp. ■ PVL significant SNPs; red square symbol: WBCs significant SNPs; ----- log₁₀(p)_PVL; red broken line: log₁₀(p)_WBC; MAF: Minimum Allele Frequency. Local LD map estimates (D´) based on 235 SNPs located within the cattle MHC region in founder maternal chromosomes. Triangles delimited with black lines identify haplotype blocks derived from Haploview [55]. The gene content of the region according to the bovine genome assembly UMD3.1 was obtained from Ensembl Genome Browser (http://www.ensembl.org). Red vertical bars indicate SNPs of the SNP50K chip located in the region