Figure 9.

Rac1 shRNA inhibits the growth of HSCC cells in vivo. (A) Mice in each group were inoculated with parental cells, Rac1 shRNA cells, or negative control cells. Thirty days after inoculation, the mice were killed and the tumor bodies were obtained. (B) The volumes of tumor bodies were measured every 3 days. (C) The weights of tumor bodies in each group. (D) HE staining was carried out to assess the histopathologic changes in each group. Scale bar=100 μm. (E) TUNEL assay was performed to detect apoptosis in each group. Scale bar=50 μm. Typical results are presented. N=6. The results are presented as mean ±SD. ** P<0.01, *** p<0.001 compared with the negative control group.