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. Author manuscript; available in PMC: 2018 Feb 14.
Published in final edited form as: Toxicol Appl Pharmacol. 2017 Jul 1;330:1–8. doi: 10.1016/j.taap.2017.06.023

Fig. 1.

Fig. 1

Effects of FGF15 deficiency on development of metabolic syndrome and steatosis. (A) Blood glucose levels were measured after administering an oral glucose challenge. The area under the curve (AUC) from the glucose-time graph was calculated for each group. (B) Body weights were measured weekly after initiating the assigned diet. Body weights of both WT and KO mice fed the HFD were significantly greater when compared to chow diet fed mice as early as day 7. (C) Isolated frozen liver sections were stained with Oil Red O (images taken at 4× magnification) and (D) relative area stained quantified. (E) Tissue concentrations of hepatic total cholesterol and triglycerides were quantified. FGF15 deficiency led to decreased hepatic total cholesterol compared to WT mice. (F) FGF15 deficiency led to increased serum triglycerides when fed HFD. (G) The relative mRNA expression of genes involved in lipid homeostasis was altered in Fgf15−/− mice. *Statistical significance between diets; #Statistical significance between WT and KO mice on corresponding diets (p ≤ 0.05).