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. Author manuscript; available in PMC: 2018 Feb 14.
Published in final edited form as: Toxicol Appl Pharmacol. 2017 Jul 1;330:1–8. doi: 10.1016/j.taap.2017.06.023

Fig. 2.

Fig. 2

Effects of FGF15 deficiency on liver histology, biomarkers, and bile homeostasis. (A) Liver sections were stained with HE. Images were taken at 20× magnification. (B) HE stained slides were scored based on NAFLD Activity Score criteria. (C and D) FGF15 deficiency led to a basal increased in ALP but attenuated the HFD induced increase in ALT. (E) KO mice fed the HFD had greater serum bile acid levels than WT mice. (F) No differences were observed in the relative mRNA expression of Tnfα and Icam1 in KO mice. (G) Relative mRNA expression of ileal Fgf15 and Ibabp, and (H) hepatic Cyp7a1, Cyp8b1, and Bsep was determined. (I) Relative protein levels of Bsep normalized to β-actin were decreased by HFD in both WT and KO. *Statistical significance between diets; #Statistical significance between WT and knockout mice on corresponding diets (p ≤ 0.05).