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. 2018 Jan 20;15:18–27. doi: 10.2142/biophysico.15.0_18

Figure 3.

Figure 3

Duplex DNA binding scheme for CPD-PHR and CRY-DASH. The base flipping of the lesion moiety will occur by the interaction between UV-damaged duplex DNA and protein. But due to the interaction of CRY-DASH is weak, the base flipping might not occur in CRY-DASH. Next, CPD-PHR and CRY-DASH recognize the lesion moiety and bind the duplex DNA. Here the binding affinity of CRY-DASH will be less than that of photolyase.