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. 2018 Feb 1;3(1):11–20. doi: 10.1089/can.2017.0041

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© Dinesh Thapa et al. 2018; Published by Mary Ann Liebert, Inc.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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FIG. 1. — Corneal chemical injury results in hyperalgesia and inflammation. (A) Pain responses to topical capsaicin challenge (1 μM) in noncauterized sham control eyes (n=5–6 per group) and cauterized eyes (n=6–10 per group) at 6 and 12 h postinjury. (B) Neutrophil expression in cauterized corneas at 6 and 12 h postinjury (n=5–6 per group). (C–E) Representative images of transverse sections of the central cornea from (C) sham control (noncauterized) corneas and cauterized corneas at (D) 6 h and (E) 12 h postinjury. Arrow in (E) points to one of many infiltrating neutrophils. Scale bar=50 μm. Values represent mean±SD. For statistical analysis, one-way ANOVA with Tukey's multiple comparison post hoc test was used. **p<0.01, *p<0.05. ANOVA, analysis of variance.