Table 4.

Effect of patient age, donor-recipient relationship, and donor age on graft failure, acute and chronic GVHD

	Graft failure, hazard ratio (95% CI)*	Acute GVHD, hazard ratio (95% CI)†	Chronic GVHD, hazard ratio (95% CI)‡
Patient age, y/donor-recipient relationship
Age 18-54/parent donor	1.00, P = .037§	1.00, P = .72§	1.00, P = .041§
Age 18-54/sibling donor	0.34 (0.16-0.70), P = .004	1.10 (0.77-1.59), P = .60	1.42 (0.93-2.17), P = .10
Age 18-54/offspring donor	0.39 (0.17-0.91), P = .029	0.84 (0.53-1.33), P = .46	1.18 (0.72-1.93), P = .52
Age 55-78/sibling donor	0.69 (0.33-1.46), P = .33	1.07 (0.67-1.69), P = .78	0.80 (0.46-1.39), P = .44
Age 55-78/offspring donor	0.62 (0.34-1.13), P = .12	0.98 (0.68-1.41), P = .93	0.70 (0.45-1.09), P = .12
Patient age/donor age, y
Age 18-54/donor age 10-29	1.00, P = .10§	1.00, P = .24§	1.00, P = .001§
Age 18-54/donor age 30-80	0.95 (0.40-2.34), P = .89	1.14 (0.83-1.57), P = .41	0.93 (0.67-1.29), P = .66
Age 55-78/donor age 10-29	2.49 (1.11-5.56), P = .03	0.77 (0.48-1.24), P = .28	0.53 (0.31-0.92), P = .02
Age 55-78/donor age 30-80	1.67 (0.86-3.26), P = .13	1.17 (0.85-1.60), P = .33	0.55 (0.38-0.80), P = .002

^*Adjusted for disease.

^†Adjusted for graft type.

‡Adjusted for graft type.

^§This P value represents the level of significance for the overall Fine and Gray model. P values for paired comparisons within the model were considered significant only when the P value for the overall model was significant.