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. 2018 Feb 1;3(2):e000303. doi: 10.1136/esmoopen-2017-000303

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© European Society for Medical Oncology (unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/

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Waterfall plot of the best per cent change from baseline in SLD of target lesions in 33 patients. Baseline is defined as the last non-missing value before the first dose of tomuzotuximab. Only patients with valid baseline and postbaseline values are included. Tumour assessment was not performed in six patients because of early withdrawal from the study following clinical deterioration or AE; two patients had no measurable disease according to RECIST1.1 criteria. The dotted lines indicate the cut-off for partial response (−30%) and progressive disease (+20%). *Patients with stable target lesions but progression because of new lesions. †Patient (CRC, dose 1370 mg) had a best change from baseline of 32.2%, unconfirmed 50 days later (change from baseline 29.5%). ¶ Patient is still in complete remission (4.5 years) and received tomuzotuximab for 5.2 years. CRC, colorectal cancer; GCA, gastric cancer; NSCLC, non-small cell lung cancer; OVCA, ovarian cancer; PanC, pancreatic cancer; RCC, renal cell cancer; SLD, sum of longest diameters.