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. Author manuscript; available in PMC: 2018 Aug 15.
Published in final edited form as: J Immunol. 2018 Jan 15;200(4):1360–1369. doi: 10.4049/jimmunol.1700891

Figure 5. Chronic soluble TL1A promotes small bowel but not systemic pathology.

Figure 5

Mice were continually infused with soluble recombinant TL1A for 6 weeks at 500 ng/day. A The Treg percentage of total CD4+ T cells and the CD44 high CD62L low percentage of CD4+ FoxP3- cells in the spleen. B The length of the small intestine was measured and sections made from the terminal ileum. These were subsequently scored for goblet cells per villi and the mean of at least 3 in-plane villi per section depicted. C qPCR analysis of cytokines from the terminal ileum. D Sections of the terminal ileum were stained with PAS; scale bars are equal to 150µm. Bar indicates median. * 0.05>P>0.01 ** 0.01>P>0.001 **** P>0.0001 using Mann Whitney test. Data combined from 2 independent experiments.