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. Author manuscript; available in PMC: 2018 Aug 15.
Published in final edited form as: J Immunol. 2018 Jan 15;200(4):1360–1369. doi: 10.4049/jimmunol.1700891

Figure 6. Systemic effects conferred by direct T cell DR3 signaling in TL1A transgenic mice.

Figure 6

A membrane restricted TL1A transgenic strain was crossed with a T cell conditional DR3-deficient strain. Phenotypes of the indicated strains were examined at 12 weeks of age. A T cell populations were examined within the spleen. The proportion of CD44 high CD62L low cells within CD4+ FoxP3- cells was examined. Proportion of Tregs (CD4+ FoxP3-) and Tfh cells (CD4+ ICOS+ CD40L+ PD1+ CXCR5+) within total CD4+ splenocytes was examined. B Serum was collected at 12 weeks of age, and total levels of the indicated antibody isotypes examined.