Figure 1.

Fungal iron homeostasis. Regulation of iron homeostasis (left panel side) is shown for different fungal species (species is color coded, shape defines phylogenetic ancestry according to Gabaldon et al. 2013). Major transcription factors upregulated during iron starvation to initiate fungal iron uptake (right panel side) are written in bold. Functional orthologs are color shaded and aligned vertically, X indicates lack of ortholog and a white box with dashed borders indicates that an ortholog is present but not involved in iron homeostasis. HA, high affinity; LA, low affinity.