Table 2. Regions with significant linkage MMLS.
| Position (cM) |
Phenotype; DRB1 Stratum | MMLS | LOD | α (%) | p-value |
|---|---|---|---|---|---|
| Chromosome 1p36.12 | |||||
| 49 | Unstratified T1D | 3.94 | -90 | 17 | NA |
| 45 | Unstratified Complications | 1.23 | -9.82 | 26 | |
| 49 | Unstratified No complications | 1.42 | -59.31 | 13 | |
| Chromosome 1q32.1 | |||||
| 215 | T1D: 3/{3,X} | 0.00 | -54 | 0 | 14.09; 2.0e-4 |
| 210 | Complications: 3/{3,X} | 3.02 | 2.79 | 89 | |
| 215 | No complications: 3/{3,X} | 0.04 | -32 | 4 | |
| Chromosome 8q21.3 | |||||
| 94 | T1D: 3/{3,X} | 2.31 | -35.81 | 16 | 3.04 (0.08) |
| 100 | Complications: 3/{3,X} | 2.88 | 2.02 | 64 | |
| 94 | No complications: 3/{3,X} | 0.09 | -14 | 10 | |
| Chromosome 12p11.21 | |||||
| 61 | T1D:X/X | 1.66 | -11 | 26 | 7.23 (0.007) |
| 54 | Complications: X/X | 0.02 | -1.54 | 13 | |
| 57 | No complications: X/X | 3.21 | -0.09 | 52 | |
| Chromosome 22q11.21 | |||||
| 12 | T1D:3/4 | 3.24 | -1.39 | 56 | 1.43 (0.23) |
| 17 | Complications:3/4 | 2.22 | 2.22 | 100 | |
| 11 | No complications:3/4 | 1.33 | -4.00 | 43 | |
Maximum MMLS, LOD, and estimated linked percentage of pedigrees (α) observed for the three phenotypes, T1D, Complications and No complications, only for the DRB1 allele strata corresponding to each linkage peak above 3.0. The last column contains the significance p-value of the pre-divided sample test.