| Cognitive function |
|
|
| Y-maze |
↓ WD |
Decrease % spontaneous alterations in WD |
| MWM |
↑ WD |
Increase % time in platform quadrant in WD in probe trial |
| RAWM |
↓ G |
Increase in the number of Trial 4 errors in LDLr -/- |
| BBB transport |
|
|
| Ki |
↑ WD |
Increased in WD |
| IHC |
|
|
| Factor VIII |
↑ G x WD |
Elevated in LDLr -/- WD (hippocampus & thalamus) |
| IBA1 |
↑ G x WD |
Elevated in WT WD (cortex & hippocampus) |
| Gene Expression (whole brain RT-PCR) |
|
| ATF3, IL-6, CD32 & CD206 |
↓G |
Reduced in LDLr -/- |
| CD86 |
↓ WD |
Reduced with WD |
|
Brain Metabolites (1H-MRS Spec)
|
|
| glutamine |
↓ G x WD |
Reduced in LDLr -/- WD |
| lip13a+13b |
↑ G x WD |
Elevated in LDLr -/- WD |
| Brain glucose utilization |
|
| 18FDG-PET |
↑ G |
Increased Standardized Uptake Value in LDLr -/- |
| Brain Metabolites (GC/MS & LC/MS) |
|
| C14 |
↑ WD |
Elevated in WD |
| C16:1 |
↑ WD |
Elevated in WD |
| Cholesterol |
↑ G x WD |
Elevated in WT WD and LDLr -/- WD |
| TCA cycle intermediates |
↑ WD |
Elevated BHB, GABA, Aspartate, 2-hydroxyguterate, Glutamine, Lactate in WD |
| Acyl-CoA's |
↑↓ G x WD |
Acetyl-CoA elevated in LDLr -/- CD, Acetyl- and Butyryl-CoA reduced in LDLr -/- WD |
| free 18 C PUFA’s |
↓ WD |
Reduced in WD |
| HETEs & leukotriene |
↑ WD |
Elevated in WD |
| Physiological |
|
|
| Weight |
↑ WD, G, and G x WD |
Increased with WD, decrease with LDLr -/- |
| Insulin |
↑ WD |
Increased with WD |
| TG |
↑ WD, G, and G x WD |
Increased in LDLr -/- and WD fed LDLr -/-, but decreased in WD fed WT |
| TC |
↑ WD, G, and G x WD |
Increased with WD or LDLr -/-, highest in LDLr -/- WD |
| HDL |
↑ WD & G |
Increased with WD or LDLr -/-, highest in LDLr -/- WD |
| LDL |
↑ G and G x WD |
Increased with WD or LDLr -/-, highest in LDLr -/- WD |
