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. 2018 Feb 14;14(2):e1006883. doi: 10.1371/journal.ppat.1006883

Fig 2. Cross-priming induces CTL responses during CPXV infection.

Fig 2

(A) BATF3+ DCs cross-prime CPXV-specific CTL precursors. B6 or Batf3-/- mice (n = 6) were infected i.p. with 1 x 105 pfu WT CPXV, ΔMHCIi, or VACV-WR, and CD8+ T cell responses were measured by ex vivo restimulation with infected DC2.4 cells and ICS at 8 dpi. The data are the combined results of three independent experiments. (B) Induction of VACV-specific CTLs is not dependent BATF3+ DCs. B6 or Batf3-/- mice (n = 6–7) were infected i.p. with 1 x 105 pfu VACV-WR and CD8+ T cell responses in the spleen were measured at 6 dpi. The data are the combined results of two independent experiments.