. Author manuscript; available in PMC: 2018 Feb 14.

Published in final edited form as: J Am Chem Soc. 2017 Jun 20;139(25):8384–8387. doi: 10.1021/jacs.7b00794

Table 1.

Biophysical Characteristics of Insulin Variants

Protein	Hexamer t_½ (s)	Fibrillation lag time(h)	K_D dimer (μM)
Prol	90.4 ± 4.2	5.1 ± 1.5	9 μM
Hzpl^*	53.6 ± 3.7	19.6 ± 2.6	~25 μM
Hypl^*	87.0 ± 10	5.5 ± 1.2	>200 μM
Aspl	42.7 ± 4.3	5.3 ± 1.0	>500 μM

Errors are given as one standard deviation (n > 4).

10% Prol present.