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. Author manuscript; available in PMC: 2018 Feb 14.
Published in final edited form as: Annu Rev Biochem. 2017 Jan 30;86:439–460. doi: 10.1146/annurev-biochem-061516-045019

Figure 4.

Figure 4

Telomerase holoenzymes are illustrated for (a) Tetrahymena thermophila, (b) Saccharomyces cerevisiae, (c) Schizosaccharomyces pombe, and (d ) vertebrates. TERs are labeled TER, TLC1, or TER1; they are greatly simplified in secondary structure representation. TERT proteins are shaded blue and labeled TERT, Est2, or Trt1. Other colors group proteins with generally related biological functions. Green arrows indicate interactions important for G-strand synthesis, and black arrows indicate interactions thought to be important for C-strand synthesis. Abbreviations: Ccq1, coiled-coil protein quantitatively enriched 1; Cdc13, cell division cycle protein 13; CST, heterotrimer containing Stn1, Ten1, and variable third subunit; Est, ever-shorter telomeres; H/ACA, hairpin-H box-hairpin-ACA motif; Ku, dimeric protein complex that binds to DNA double-strand break ends; Lsm, like Sm; nt, nucleotide; PolαPrimase, polymerase α primase; p19-p45-p75, Tetrahymena telomerase CST with subunits of 19, 45, and 75 kDa; p65, Tetrahymena telomerase subunit of 65 kDa; Pop, processing of precursor RNAs; Sm proteins, proteins identified by Sm serotype antibodies from patients with autoimmune disease; Stn1, suppressor of cdc thirteen 1; TCAB1, telomerase and Cajal body protein 1; Teb1, telomeric repeat binding subunit 1; TEB, Teb1 heterotrimer complex; Ten1, telomeric pathways in association with Stn1, number 1; TER, telomerase RNA; TERT, telomerase reverse transcriptase; TLC1, S. cerevisiae TER identified as telomerase component 1; TPP1, vertebrate shelterin protein designation for proteins initially named TINT1/PTOP/PIP1; Tpz1, TPP1 homolog in S. pombe; Trt1, TERT of S. pombe.