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. Author manuscript; available in PMC: 2018 Feb 14.
Published in final edited form as: Breast Cancer Res Treat. 2016 Dec 22;161(3):567–574. doi: 10.1007/s10549-016-4083-6

Table 1.

Results of in vitro growth experiments, IC50 values, calculated IC50 ratios and average

Experiment 1
Experiment 2
Experiment 3
Average IC50 ratios
IC50 (nM) IC50 ratio IC50 (nM) IC50 ratio IC50 (nM) IC50 ratio
Tamoxifen 106 1   88 1 188 1 1
N-desmethyltamoxifen 189 0.56 573 0.15 430 0.44 0.38
(Z)-4-hydroxytamoxifen   18 5.89     7 12.6     4 47 21.8
(Z)-Endoxifen     8 13.3     4 22     1 188 74.4

IC50 = half maximal inhibitory concentration