Respiratory function.
WT | mdx | p47-/-/mdx | |
---|---|---|---|
f (breath/min) | 408.2 ± 14.5 * | 279.8 ± 18.3 | 377.3 ± 17.0 * |
Tv (ml) | 0.25 ± 0.009 | 0.24 ± 0.008 | 0.26 ± 0.012 |
Mv (ml) | 100.3 ± 5.6 * | 65.9 ± 17.6 | 99.2 ± 8.6 * |
PIF (ml/s) | 7.6 ± 0.30 * | 5.9 ± 0.56 | 8.0 ± 0.51 * |
PEF (ml/s) | 4.2 ± 0.25 | 3.2 ± 0.24 | 4.4 ± 0.39 * |
Ti (s) | 0.057 ± 0.002 * | 0.080 ± 0.007 | 0.057 ± 0.002 * |
Te (s) | 0.129 ± 0.009 * | 0.190 ± 0.012 | 0.138 ± 0.008 * |
Dystrophic mice lacking Nox 2 ROS production maintained respiratory function similar to WT levels. p≤0.05 *Significant difference vs. mdx in at least nanimals = 9.