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. 2018 Jan 30;7:e31732. doi: 10.7554/eLife.31732

Respiratory function.

WT mdx p47-/-/mdx
f (breath/min) 408.2 ± 14.5 * 279.8 ± 18.3 377.3 ± 17.0 *
Tv (ml) 0.25 ± 0.009 0.24 ± 0.008 0.26 ± 0.012
Mv (ml) 100.3 ± 5.6 * 65.9 ± 17.6 99.2 ± 8.6 *
PIF (ml/s) 7.6 ± 0.30 * 5.9 ± 0.56 8.0 ± 0.51 *
PEF (ml/s) 4.2 ± 0.25 3.2 ± 0.24 4.4 ± 0.39 *
Ti (s) 0.057 ± 0.002 * 0.080 ± 0.007 0.057 ± 0.002 *
Te (s) 0.129 ± 0.009 * 0.190 ± 0.012 0.138 ± 0.008 *

Dystrophic mice lacking Nox 2 ROS production maintained respiratory function similar to WT levels. p≤0.05 *Significant difference vs. mdx in at least nanimals = 9.