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. Author manuscript; available in PMC: 2018 Dec 27.
Published in final edited form as: J Am Chem Soc. 2017 Dec 15;139(51):18409–18427. doi: 10.1021/jacs.7b08418

Scheme 2.

Scheme 2

Generic reaction mechanism for the reversible oxidation of a primary alcohol by Zn(II)-dependent alcohol dehydrogenases. Proton transfer to a general base (B) accompanies the hydride transfer to NAD+.