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. 2017 Apr 17;152(3):478–485. doi: 10.1016/j.chest.2017.03.050

Figure 4.

Figure 4

FcγRIIa HH131 platelets are most susceptible to inhibition by IVIg. IVIg was added to serum from two patients with severe HIT (A, HIT patient 1 and B, HIT patient 2) to produce IgG concentrations achieved after treatment with IVIg at doses shown on the abscissa (see Methods section). Samples were then tested in the PEA (low PF4) using platelets from donors with RR, HR, and HH131 FcγRIIa genotypes. P-selectin expression (percent of value obtained with untreated serum) is shown on the ordinate. Figures show mean + 1 SD of triplicate measurements. Mean values were compared using the Student t test. Asterisks denote P < .05 (*), P < .01 (**), P < .001, (***), and P < .0001 (****). See Figures 1 and 3 legends for expansion of abbreviations.